SYNTHROID- levothyroxine sodium tablet
Closely monitor blood pressure and heart rate in these patients. Seizures have been reported rarely with the institution of levothyroxine therapy. Administer SYNTHROID at least 4 hours before or after drugs known to interfere with SYNTHROID absorption see DRUG INTERACTIONS. Our Synthroid Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
Patient Handout
Treat synthroid aggression patients with adrenal insufficiency with replacement glucocorticoids prior to initiating treatment with SYNTHROID see CONTRAINDICATIONS. Carefully monitor glycemic control, especially when thyroid therapy is started, changed, or discontinued see WARNINGS AND PRECAUTIONS. Hypersensitivity reactions to inactive ingredients have occurred in patients treated with thyroid hormone products.
The SYNTHROID dosage is based on the target level of TSH suppression for the stage and clinical status of thyroid cancer. Start at a lower starting dosage and increase the dosage every 4 to 6 weeks as needed based on clinical and laboratory response. Synthroid is also used in patients who need surgery and radioiodine therapy to manage a type of thyroid cancer called well-differentiated thyroid cancer. Consumption of certain foods may affect SYNTHROID absorption thereby necessitating adjustments in dosing see Dosage and Administration (2.1).
Dosing And Administration
The signs and symptoms of overdosage are those of hyperthyroidism see Warnings and Precautions (5) and Adverse Reactions (6). Seizures occurred in a 3-year-old child ingesting 3.6 mg of levothyroxine. Symptoms may not necessarily be evident or may not appear until several days after ingestion of levothyroxine sodium. The signs and symptoms of overdosage are those of hyperthyroidism see WARNINGS AND PRECAUTIONS and Adverse Reactions.
Soybean flour, cottonseed meal, walnuts, and dietary fiber may bind and decrease the absorption of SYNTHROID from the gastrointestinal tract. Grapefruit juice may delay the absorption of levothyroxine and reduce its bioavailability. Inquire whether patients are taking biotin or biotin-containing supplements.
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- Oral levothyroxine sodium is a synthetic T4 hormone that exerts the same physiologic effect as endogenous T4, thereby maintaining normal T4 levels when a deficiency is present.
- Do not administer in foods that decrease absorption of SYNTHROID, such as soybean-based infant formula see DRUG INTERACTIONS.
DRUG INTERACTIONS
- The peak therapeutic effect of a given dose of SYNTHROID may not be attained for 4 to 6 weeks.
- Since postpartum TSH levels are similar to preconception values, the SYNTHROID dosage should return to the pre-pregnancy dose immediately after delivery see DOSAGE AND ADMINISTRATION.
- Administer SYNTHROID as a single daily dose, on an empty stomach, one-half to one hour before breakfast.
Toxic effects may include increased risk of cardiac arrhythmias and central nervous system stimulation. Administration of sertraline in patients stabilized on SYNTHROID may result in increased SYNTHROID requirements. For adult patients with primary hypothyroidism, titrate until the patient is clinically euthyroid and the serum TSH returns to normal. Rapid restoration of normal serum T4 concentrations is essential for preventing the adverse effects of congenital hypothyroidism on cognitive development as well as on overall physical growth and maturation.
Concurrent use of sympathomimetics and SYNTHROID may increase the effects of sympathomimetics or thyroid hormone. Thyroid hormones may increase the risk of coronary insufficiency when sympathomimetic agents are administered to patients with coronary artery disease. Therefore, a decrease in the dose of anticoagulant may be warranted with correction of the hypothyroid state or when the SYNTHROID dose is increased. Closely monitor coagulation tests to permit appropriate and timely dosage adjustments. Do not administer in foods that decrease absorption of SYNTHROID, such as soybean-based infant formula see DRUG INTERACTIONS.
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Decreased bone mineral density with over-replacement
Many drugs and physiologic conditions affect the binding of thyroid hormones to serum proteins see Drug Interactions (7). Thyroid hormones do not readily cross the placental barrier see Use in Specific Populations (8.1). Many drugs and physiologic conditions affect the binding of thyroid hormones to serum proteins see DRUG INTERACTIONS. Thyroid hormones do not readily cross the placental barrier see Use In Specific Populations. Because of the increased prevalence of cardiovascular disease among the elderly, initiate SYNTHROID at less than the full replacement dose see DOSAGE AND ADMINISTRATION and WARNINGS AND PRECAUTIONS. Initiate SYNTHROID therapy in this population at lower doses than those recommended in younger individuals or in patients without cardiac disease see DOSAGE AND ADMINISTRATION and Use In Specific Populations.
Prevention of hyperthyroidism or incomplete treatment of hypothyroidism
Levothroid is used for hashimoto’s disease, hypothyroidism, after thyroid removal, myxedema coma … Eltroxin is used for hashimoto’s disease, hypothyroidism, after thyroid removal, myxedema coma … Unithroid is used for hashimoto’s disease, hypothyroidism, after thyroid removal, myxedema coma … Tirosint is used for hashimoto’s disease, hypothyroidism, after thyroid removal, myxedema coma … You may not be able to take Synthroid if you have certain medical conditions.